In the quality management context, iodometric refers to a type of titration method used in analytical chemistry to quantify the concentration of oxidizing agents in a sample through the use of iodine. While not specific to quality management per se, iodometric titration is a crucial analytical technique employed in quality control laboratories across various industries to ensure the compliance of raw materials, intermediates, and finished products with specified quality standards.

General Description

Iodometric titration involves the indirect determination of oxidizing agents by reacting them with an excess of iodide under acidic conditions to produce iodine, which is then titrated with a standard solution of sodium thiosulfate until all iodine is reduced, indicating the endpoint. This method is highly accurate, sensitive, and adaptable for quantifying the presence of substances like copper, chlorine, hydrogen peroxide, and other oxidants in a sample.

Areas of Application

  • Pharmaceutical Industry: For determining the strength and purity of drug substances and ensuring the stability of pharmaceutical products.
  • Water Treatment: To measure the concentration of disinfectants like chlorine and ensure the safety and quality of drinking water.
  • Food Industry: In assessing the quality and safety of food ingredients, especially in testing for preservatives and antioxidants.
  • Chemical Manufacturing: For quality control of raw materials and chemical products, especially those that are sensitive to oxidation.

Well-Known Examples

  • Determination of vitamin C content in food and pharmaceutical products by its oxidizing effect on iodide.
  • Analysis of chlorine levels in water treatment facilities to ensure proper disinfection without exceeding regulatory limits.


The main risks associated with iodometric titration in quality management include the potential for measurement inaccuracies due to improper sample preparation, human error in titration procedures, or instability of reagents like iodine. Accurate results are crucial for making informed decisions regarding product quality and safety.


To mitigate these risks and ensure the reliability of iodometric titration results:

  • Standard operating procedures (SOPs) should be strictly followed.
  • Analysts should be properly trained in titration techniques.
  • Reagents and solutions must be prepared and stored correctly to maintain their stability and reactivity.
  • Quality control checks and calibration of equipment should be performed regularly.

History and Legal Basics

The development of iodometric titration dates back to the 19th century as one of the earliest titrimetric methods. Its principles and applications have been refined over the years, making it a staple technique in analytical chemistry. In quality management, regulatory standards such as those set by the International Organization for Standardization (ISO), the United States Pharmacopeia (USP), and the European Pharmacopoeia (EP) often specify iodometric methods for certain tests, reflecting its importance in maintaining product quality and compliance.


Iodometric titration is a valuable analytical technique in quality management for the quantitative determination of oxidizing agents in various industries. Its accuracy and versatility in measuring the concentration of specific substances make it essential for ensuring product quality and compliance with health and safety standards. Proper technique, adherence to SOPs, and regular quality checks are critical to obtaining reliable and accurate results.

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